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Yukihiro Matsuyama Selected Research

Intervertebral Disc Chemolysis (Discolysis)

7/2022Disc degeneration could be recovered after chemonucleolysis with condoliase.-1 year clinical outcome of condoliase therapy.
5/2022Condoliase chemonucleolysis for lumbar disc herniation: A post-hoc follow-up study of patients in previous clinical trials.
1/2018A multicenter, randomized, double-blind, dose-finding study of condoliase in patients with lumbar disc herniation.
1/2018Condoliase for the Treatment of Lumbar Disc Herniation: A Randomized Controlled Trial.

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Yukihiro Matsuyama Research Topics

Disease

26Congenital Abnormalities (Deformity)
10/2022 - 05/2008
17Spinal Cord Injuries (Spinal Cord Injury)
07/2022 - 09/2004
15Spinal Cord Diseases
08/2021 - 04/2002
13Kyphosis
06/2022 - 12/2005
10Scoliosis
02/2022 - 04/2002
10Neoplasms (Cancer)
05/2021 - 03/2007
9Osteoporosis
06/2022 - 06/2005
8Pain (Aches)
07/2022 - 08/2004
8Rheumatoid Arthritis
03/2021 - 02/2005
7Intervertebral Disc Displacement (Herniated Disc)
07/2022 - 04/2002
7Paralysis (Palsy)
08/2021 - 09/2009
6Wounds and Injuries (Trauma)
09/2021 - 03/2009
6Low Back Pain (Lumbago)
01/2021 - 07/2006
6Cysts
01/2021 - 01/2014
5Pathologic Constriction (Stenosis)
12/2021 - 04/2002
5Surgical Wound Infection
01/2021 - 06/2015
5Infections
07/2020 - 07/2005
4Hemorrhage
01/2021 - 08/2004
4Spinal Cord Compression
05/2017 - 12/2005
3Back Pain (Backache)
07/2022 - 01/2017
3Body Weight (Weight, Body)
11/2021 - 06/2017
3Ependymoma
01/2021 - 03/2007
3Neuralgia (Stump Neuralgia)
01/2021 - 01/2017
3Lordosis
12/2020 - 12/2011
3Hypersensitivity (Allergy)
01/2019 - 11/2014
3Peripheral Nerve Injuries
01/2019 - 01/2016
2Disease Progression
10/2022 - 01/2017
2Intervertebral Disc Degeneration
07/2022 - 01/2009
2Spinal Cord Neoplasms (Spinal Cord Tumors)
01/2022 - 04/2019
2Malnutrition (Nutritional Deficiencies)
09/2021 - 01/2021
2Neural Tube Defects (Exencephaly)
05/2021 - 09/2016
2Hypesthesia (Numbness)
01/2021 - 06/2006
2Spondylolisthesis
01/2021 - 02/2005
2Neurologic Manifestations (Neurological Manifestations)
01/2019 - 08/2004
2Bone Resorption
01/2018 - 03/2017
2Renal Insufficiency (Renal Failure)
06/2017 - 06/2005
2Hip Fractures (Intertrochanteric Fractures)
06/2017 - 07/2016
2Knee Osteoarthritis
11/2016 - 09/2016
2Osteoarthritis
09/2016 - 01/2014
2Cicatrix (Scar)
11/2014 - 09/2011
2Osteophyte
12/2011 - 05/2007
1Stroke (Strokes)
07/2022
1Muscle Weakness
12/2021
1Hypertrophy
12/2021
1Neutropenia
12/2021

Drug/Important Bio-Agent (IBA)

5SteroidsIBA
05/2021 - 06/2006
42-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA
12/2021 - 05/2017
4LipidsIBA
12/2021 - 06/2012
4YM 529IBA
03/2019 - 07/2016
4EnzymesIBA
01/2018 - 01/2005
3Pharmaceutical PreparationsIBA
01/2021 - 11/2015
3Chondroitin Sulfates (Chondroitin Sulfate)IBA
03/2012 - 03/2009
3Keratan SulfateIBA
11/2011 - 03/2009
3Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
01/2005 - 10/2004
2Diphosphonates (Bisphosphonates)IBA
06/2022 - 01/2018
2TESIBA
03/2022 - 10/2019
2Granulocyte Colony-Stimulating Factor (G-CSF)IBA
12/2021 - 01/2018
2SuspensionsIBA
05/2021 - 04/2019
2VancomycinFDA LinkGeneric
01/2021 - 07/2019
2PowdersIBA
01/2021 - 07/2019
2Povidone-Iodine (Betadine)FDA LinkGeneric
11/2019 - 06/2015
2Peptides (Polypeptides)IBA
11/2019 - 01/2013
2Phosphatidylcholines (Phosphatidylcholine)IBA
01/2019 - 01/2016
2Arachidonic Acid (Vitamin F)IBA
01/2019 - 01/2016
2ProstaglandinsIBA
06/2012 - 01/2005
2Proteoglycans (Proteoglycan)IBA
03/2012 - 11/2011
2Biological ProductsIBA
03/2012 - 04/2010
2ElementsIBA
11/2009 - 02/2003
2Transforming Growth Factor beta1 (TGF beta 1)IBA
03/2009 - 05/2007
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
03/2007 - 01/2005
27- chloro- 3- imino- 5- methyl- 2- azabicyclo(4.1.0)heptaneIBA
01/2005 - 09/2004
1DenosumabFDA Link
06/2022
1HomocysteineIBA
06/2022
1Cystatin CIBA
06/2022
1CreatinineIBA
06/2022
1CytokinesIBA
12/2021

Therapy/Procedure

20Decompression
07/2022 - 08/2004
15Therapeutics
07/2022 - 06/2006
13Osteotomy
10/2022 - 09/2016
10Laminectomy
01/2022 - 12/2005
9Operative Surgical Procedures
10/2022 - 07/2006
6Spinal Fusion (Spondylosyndesis)
11/2021 - 01/2016
6Knee Replacement Arthroplasty (Total Knee Replacement)
09/2021 - 07/2010
6Laminoplasty
11/2010 - 10/2004
5Reoperation
10/2022 - 04/2018
4Intervertebral Disc Chemolysis (Discolysis)
07/2022 - 01/2018
4Pedicle Screws
02/2022 - 05/2008
4Activities of Daily Living (ADL)
12/2020 - 02/2005
3Hip Replacement Arthroplasty (Total Hip Replacement)
02/2021 - 06/2017
3Conservative Treatment
06/2015 - 12/2005
2Radiotherapy
01/2022 - 07/2009
2Drug Therapy (Chemotherapy)
03/2021 - 01/2017
2Anesthesia
01/2021 - 05/2016
2Diskectomy (Discectomy)
01/2021 - 07/2006
2Length of Stay
01/2021 - 10/2018
2Sutures (Suture)
10/2019 - 09/2011
2Arthroplasty
07/2019 - 09/2012
2Meniscectomy
01/2016 - 01/2014
2Foraminotomy
08/2012 - 05/2010
1Transcranial Direct Current Stimulation
03/2022